Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
Altered DNA methylation is a feature of cancer and between-patient variability is prevalent. Here, the authors integrate data on thousands of human tumours, and find that expression levels of methionine metabolism genes are predictive of methylation features, and that the breakdown of this relations...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13666 |