Design of novel analogues of t-DPH1 with reduced cytotoxicity, taking the three conserved characteristics of the dermaseptin family as the feasible starting point

Design of novel analogues of t-DPH1 with reduced cytotoxicity, taking the three conserved characteristics of the dermaseptin family as the feasible starting point

In recent years, there has been growing scientific interest in balancing the bioactivity and cytotoxicity of antimicrobial peptides (AMPs) for more comprehensive research and application. In this study, we focused on t-DPH1, a representative member of the dermaseptin family, as a template. We synthe...

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Bibliographic Details
Main Authors: Haixin Qin, Weimin Zuo, Siyuan Luo, Lilin Ge, Lei Wang, Xiaoling Chen, Chengbang Ma, Hong-Ye Li, Tianbao Chen, Mei Zhou, Hang Fai Kwok
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Arabian Journal of Chemistry
Subjects:
Antimicrobial peptide
Dermaseptin peptide
Peptide modification
Peptide cytotoxicity
Antibiotic and antiancer protoype drug
C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223008821

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http://www.sciencedirect.com/science/article/pii/S1878535223008821

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