Discovery of the first PD-1 ligand encoded by a pathogen

Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The programmed death-1 (PD-1) receptor and its li...

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Bibliographic Details
Main Authors: Pablo Martínez-Vicente, Francesc Poblador, Judith Leitner, Domènec Farré, Peter Steinberger, Pablo Engel, Ana Angulo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007334/full