Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma

Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma

Trastuzumab as a first HER2-targeted therapy for the treatment of HER2-positive breast cancer patients was introduced in 1998. Although trastuzumab has opened a new avenue to treat patients with HER2-positive breast cancer and other types of cancer, some patients are not responsive or become resista...

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Bibliographic Details
Main Authors: Hamid Maadi, Mohammad Hasan Soheilifar, Won-Shik Choi, Abdolvahab Moshtaghian, Zhixiang Wang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
trastuzumab
breast cancer
HER2
PI3K/AKT pathway
MAPK pathway
Online Access:https://www.mdpi.com/2072-6694/13/14/3540

Internet

https://www.mdpi.com/2072-6694/13/14/3540

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