Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing

Activation of AMPK Enhances Neutrophil Chemotaxis and Bacterial Killing

Abstract An inability of neutrophils to eliminate invading microorganisms is frequently associated with severe infection and may contribute to the high mortality rates associated with sepsis. In the present studies, we examined whether metformin and other 5′ adenosine monophosphate-activated protein...

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Bibliographic Details
Main Authors: Dae Won Park, Shaoning Jiang, Jean-Marc Tadie, William S. Stigler, Yong Gao, Jessy Deshane, Edward Abraham, Jaroslaw W. Zmijewski
Format: Article
Language:English
Published: BMC 2013-10-01
Series:Molecular Medicine
Subjects:
Adenosine Monophosphate-activated Protein Kinase (AMPK)
Neutrophil Chemotaxis
Bacterial Killing
AMPK Activation
Aminoimidazole Carboxamide Ribonucleotide (AICAR)
Online Access:https://doi.org/10.2119/molmed.2013.00065

Internet

https://doi.org/10.2119/molmed.2013.00065

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