Proton currents constrain structural models of voltage sensor activation
The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...
| Main Authors: | , , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
eLife Sciences Publications Ltd
2016-08-01
|
| 丛编: | eLife |
| 主题: | |
| 在线阅读: | https://elifesciences.org/articles/18017 |