Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside

Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside

A specific plasma membrane distribution of the mechanosensitive ion channel Piezo1 is required for cell migration, but the mechanism remains elusive. Here, we addressed this question using WT and <i>Piezo1</i>-silenced C2C12 mouse myoblasts and WT and <i>Piezo1</i>-KO human k...

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Bibliographic Details
Main Authors: Juliette Vanderroost, Thibaud Parpaite, Noémie Avalosse, Patrick Henriet, Christophe E. Pierreux, Joseph H. Lorent, Philippe Gailly, Donatienne Tyteca
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
lipid domains
calcium live cell imaging
Fura-2 polarization
lipid lateral diffusion
Piezo1 KO cells
mechanosensitive channels
Online Access:https://www.mdpi.com/2073-4409/12/24/2784

Internet

https://www.mdpi.com/2073-4409/12/24/2784

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