Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model

Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model

Osteoarthritis (OA) is a degenerative disease that is difficult to cure owing to its complicated pathogenesis. Exercise therapy has been endorsed as a primary treatment option. However, it remains controversial how exercise intensity regulates OA progression. Here, a declining propensity for TGF-β1...

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Bibliographic Details
Main Authors: Yang Wang, Zhuangzhuang Jin, Shuangshuo Jia, Peng Shen, Yue Yang, Ying Huang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Exercise therapy
Mechanical stimulation
TGF-β1
Chondrocyte
Osteoarthritis
Pyroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000045

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http://www.sciencedirect.com/science/article/pii/S0753332223000045

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