CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells

CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells

Lymph node (LN) plays a critical role in tumor cell survival outside of the primary tumor sites and dictates overall clinical response in many tumor types (1, 2). Previously, we and others have demonstrated that CCL3 plays an essential role in orchestrating T cell—antigen-presenting cell (APC) encou...

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Bibliographic Details
Main Authors: Frederick Allen, Peter Rauhe, David Askew, Alexander A. Tong, Joseph Nthale, Saada Eid, Jay T. Myers, Caryn Tong, Alex Y. Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
CCL3
natural killer cells
CD103+ dendritic cells
lymphocytes
interferon-gamma
lymph node
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01390/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01390/full

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