Structure-Based Discovery of <i>N</i>-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication

Structure-Based Discovery of <i>N</i>-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication

As a key element during HBV replication, a nucleocapsid is considered a promising target for the treatment of chronic hepatitis B. The present study aimed to identify small molecules as novel capsid assembly modulators with antiviral activity. Structure-based virtual screening of an integrated compo...

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Bibliographic Details
Main Authors: Yang Yang, Yu Yan, Jiaxin Yin, Jie Hu, Xuefei Cai, Jieli Hu, Jie Xia, Kai Wang, Ni Tang, Luyi Huang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
hepatitis B virus
core protein
capsid
assembly modulator
antiviral activity
Online Access:https://www.mdpi.com/1999-4915/14/2/348

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https://www.mdpi.com/1999-4915/14/2/348

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