Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication

Background The survival of patients with cervical cancer who are treated with cisplatin in conjunction with the topoisomerase I inhibitor topotecan is enhanced when compared with patients treated with only one of these chemotherapeutics. Moreover, cisplatin-based and T cell-based immunotherapy have...

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Bibliographic Details
Main Authors: Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Cornelis J M Melief, Tetje C van der Sluis, Ward Vleeshouwers, Floortje J van Haften, Iris N Pardieck, J Fréderique de Graaf, Koen van der Maaden
Format: Article
Language:English
Published: BMJ Publishing Group 2023-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/11/e007158.full

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https://jitc.bmj.com/content/11/11/e007158.full

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