The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer’s Disease

The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. Synaptic dysfunction is an integral feature of AD pathophysiology and a significant factor in early cognitive impairment in AD. Microglia, which are intrinsic immune cells in the central nervous system, play important regulatory ro...

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Bibliographic Details
Main Authors: Qi Qin, Meng Wang, Yunsi Yin, Yi Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Alzheimer disease
synaptic clearance
microglia
TREM2 (triggering receptor expressed on myeloid cells)
APOE
complement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.845897/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.845897/full

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