The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer’s Disease

The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. Synaptic dysfunction is an integral feature of AD pathophysiology and a significant factor in early cognitive impairment in AD. Microglia, which are intrinsic immune cells in the central nervous system, play important regulatory ro...

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Bibliographic Details
Main Authors:	Qi Qin, Meng Wang, Yunsi Yin, Yi Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Immunology
Subjects:	Alzheimer disease synaptic clearance microglia TREM2 (triggering receptor expressed on myeloid cells) APOE complement
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.845897/full

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