mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts

mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts

The reduction of protein translation is a common feature in senescent cells and aging organisms, yet the underlying mechanisms are not fully understood. Here we show that both global mRNA translation and mammalian/mechanistic target of rapamycin complex 1 (mTORC1) kinase activity are declined in a s...

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Bibliographic Details
Main Authors: Su Wu, Siyao Xu, Ruofei Li, Kecheng Li, Xiaoqin Zhong, Yingying Li, Zhifen Zhou, Yi Liu, Ran Feng, Jianfei Zheng, Zhou Songyang, Feng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell senescence
MEF
mRNA translation
mTORC1
Rps15
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00337/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00337/full

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