The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.

Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little is known of the underlying mechanism(s). Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1α) to initiate X-box-binding protein 1 (Xb...

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Bibliographic Details
Main Authors: Justin R Hassler, Donalyn L Scheuner, Shiyu Wang, Jaeseok Han, Vamsi K Kodali, Philip Li, Julie Nguyen, Jenny S George, Cory Davis, Shengyang P Wu, Yongsheng Bai, Maureen Sartor, James Cavalcoli, Harmeet Malhi, Gregory Baudouin, Yaoyang Zhang, John R Yates, Pamela Itkin-Ansari, Niels Volkmann, Randal J Kaufman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002277

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https://doi.org/10.1371/journal.pbio.1002277

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