The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 Motility

The ALS-Associated FUS (P525L) Variant Does Not Directly Interfere with Microtubule-Dependent Kinesin-1 Motility

Deficient intracellular transport is a common pathological hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Mutations in the fused-in-sarcoma (FUS) gene are one of the most common genetic causes for familial ALS. Motor neurons carrying a mutation in the nuc...

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Bibliographic Details
Main Authors: Anne Seifert, Hauke Drechsler, Julia Japtok, Till Korten, Stefan Diez, Andreas Hermann
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
motor neurons
axonopathy
molecular motors
axonal transport
gliding motility assays
Online Access:https://www.mdpi.com/1422-0067/22/5/2422

Internet

https://www.mdpi.com/1422-0067/22/5/2422

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