Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1

Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1

Summary 1. Kindlin-3 but not talin-1 contributes to integrin inside-out signaling induced β2 integrin clustering. 2. The Pleckstrin homology domain of kindlin-3 was critical for its mediated β2 integrin clustering.

Bibliographic Details
Main Authors: Yuanyuan Wu, Ziming Cao, Wei Liu, Jason G. Cahoon, Kepeng Wang, Penghua Wang, Liang Hu, Yunfeng Chen, Markus Moser, Anthony T. Vella, Klaus Ley, Lai Wen, Zhichao Fan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Neutrophil adhesion
β2 integrin
Integrin clustering
Kindlin-3
Talin-1
STORM
Online Access:https://doi.org/10.1186/s12964-024-02024-8

Internet

https://doi.org/10.1186/s12964-024-02024-8

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