Computational POM and DFT Evaluation of Experimental in-vitro Cancer Inhibition of Staurosporine-Ruthenium(II) Complexes: The Power Force of Organometallics in Drug Design

Computational POM and DFT Evaluation of Experimental in-vitro Cancer Inhibition of Staurosporine-Ruthenium(II) Complexes: The Power Force of Organometallics in Drug Design

A computational Petra/Osiris/Molinspiration/DFT(POM/DFT) based model has been developed for the identification of physic-chemical parameters governing the bioactivity of  Ruthenium-Staurosporine complexes 2-4 containing an antitumoral-Kinase (TK) pharmacophore sites. The four compounds 1-4 analyzed...

Full description

Bibliographic Details
Main Authors: Taibi Ben Hadda, Zuhal Karagoz Genc, Vijay H. Masand, Nadia Nebbache, Ismail Warad, Shehdeh Jodeh, Murat Genc, Yahia N. Mabkhot, Assem Barakat, Hector Salgado Zamora
Format: Article
Language:English
Published: Slovenian Chemical Society 2015-03-01
Series:Acta Chimica Slovenica
Subjects:
Cancer-Kinase (CK), antitumor agents, Ruthenium-Staurosporine complexes, DFT, Petra/Osiris/Molinspiration (POM) analyses
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/1357

Internet

https://journals.matheo.si/index.php/ACSi/article/view/1357

Similar Items