Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both <i>Ppara</i>-null and <i>PPARA</i>-humanized mice, yet both lines develop age-related liver cancer...

Full description

Bibliographic Details
Main Authors: Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Metabolites
Subjects:
peroxisome proliferator-activated receptor-α (PPARα)
hepatocarcinogenesis
linoleic acid
CD4<sup>+</sup> T cell
senescence
Online Access:https://www.mdpi.com/2218-1989/13/8/936

Internet

https://www.mdpi.com/2218-1989/13/8/936

Similar Items