Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both <i>Ppara</i>-null and <i>PPARA</i>-humanized mice, yet both lines develop age-related liver cancer...

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Podrobná bibliografie
Hlavní autoři: Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2023-08-01
Edice:Metabolites
Témata:
peroxisome proliferator-activated receptor-α (PPARα)
hepatocarcinogenesis
linoleic acid
CD4<sup>+</sup> T cell
senescence
On-line přístup:https://www.mdpi.com/2218-1989/13/8/936

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https://www.mdpi.com/2218-1989/13/8/936

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