Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in <i>Ppara</i> Transgenic Mice

Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both <i>Ppara</i>-null and <i>PPARA</i>-humanized mice, yet both lines develop age-related liver cancer...

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Bibliografiske detaljer
Main Authors:	Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Format:	Article
Sprog:	English
Udgivet:	MDPI AG 2023-08-01
Serier:	Metabolites
Fag:	peroxisome proliferator-activated receptor-α (PPARα) hepatocarcinogenesis linoleic acid CD4<sup>+</sup> T cell senescence
Online adgang:	https://www.mdpi.com/2218-1989/13/8/936

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