Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons

Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons

An important post-translational modification (PTM) of α-tubulin is the removal of amino acids from its C-terminus. Removal of the C-terminal tyrosine residue yields detyrosinated α-tubulin, and subsequent removal of the penultimate glutamate residue produces ΔC2-α-tubulin. These PTMs alter the abili...

Full description

Bibliographic Details
Main Authors: Takashi Hotta, Alexandra Plemmons, Margo Gebbie, Trevor A. Ziehm, Teresa Lynne Blasius, Craig Johnson, Kristen J. Verhey, Jillian N. Pearring, Ryoma Ohi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
tubulin
detyrosination
ΔC2-tubulin
VASOHIBIN
cytosolic carboxypeptidase (CCP)
Online Access:https://www.mdpi.com/2218-273X/13/2/357

Internet

https://www.mdpi.com/2218-273X/13/2/357

Similar Items