d-Ribose as a Contributor to Glycated Haemoglobin

d-Ribose as a Contributor to Glycated Haemoglobin

Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order...

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Bibliographic Details
Main Authors: Xixi Chen, Tao Su, Yao Chen, Yingge He, Ying Liu, Yong Xu, Yan Wei, Juan Li, Rongqiao He
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:EBioMedicine
Subjects:
d-ribose
HbA1c
Type 2 diabetes mellitus
Transketolase
Benfotiamine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303936

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http://www.sciencedirect.com/science/article/pii/S2352396417303936

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