Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension
Recent studies have reported that components of the renin-angiotensin system (RAS) are expressed in venous malformations by embryonic stem cell-like subpopulations. It has been hypothesized that these cells are sustained by the RAS and, therefore, could be a novel therapeutic target, using medicatio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Vascular Surgery Cases and Innovative Techniques |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468428722001769 |
| _version_ | 1828085486853292032 |
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| author | Sigurd Berger, MD Therese Halvorsen Bjark, MD Karsten Midtvedt, MD, PhD Rune Andersen, MD |
| author_facet | Sigurd Berger, MD Therese Halvorsen Bjark, MD Karsten Midtvedt, MD, PhD Rune Andersen, MD |
| author_sort | Sigurd Berger, MD |
| collection | DOAJ |
| description | Recent studies have reported that components of the renin-angiotensin system (RAS) are expressed in venous malformations by embryonic stem cell-like subpopulations. It has been hypothesized that these cells are sustained by the RAS and, therefore, could be a novel therapeutic target, using medications such as angiotensin-converting enzyme inhibitors. A young man with a symptomatic intramuscular venous malformation of the upper limb, and hypertension was treated with an angiotensin-converting enzyme inhibitor. After 8 months of treatment, we registered a considerable volume reduction of the venous malformation and a reduction in pain. Our observation warrants further research on the link between the RAS and venous malformations. |
| first_indexed | 2024-04-11T04:40:51Z |
| format | Article |
| id | doaj.art-105084adfb894c0984481ab05605ad9e |
| institution | Directory Open Access Journal |
| issn | 2468-4287 |
| language | English |
| last_indexed | 2024-04-11T04:40:51Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Vascular Surgery Cases and Innovative Techniques |
| spelling | doaj.art-105084adfb894c0984481ab05605ad9e2022-12-28T04:18:56ZengElsevierJournal of Vascular Surgery Cases and Innovative Techniques2468-42872022-12-0184657659Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertensionSigurd Berger, MD0Therese Halvorsen Bjark, MD1Karsten Midtvedt, MD, PhD2Rune Andersen, MD3Department of Radiology and Nuclear Medicine, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Correspondence: Sigurd Berger, MD, Department of Radiology and Nuclear Medicine, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Postboks 4950, Nydalen, Oslo 0424, NorwayDepartment of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, NorwayDepartment of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, NorwayDepartment of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayRecent studies have reported that components of the renin-angiotensin system (RAS) are expressed in venous malformations by embryonic stem cell-like subpopulations. It has been hypothesized that these cells are sustained by the RAS and, therefore, could be a novel therapeutic target, using medications such as angiotensin-converting enzyme inhibitors. A young man with a symptomatic intramuscular venous malformation of the upper limb, and hypertension was treated with an angiotensin-converting enzyme inhibitor. After 8 months of treatment, we registered a considerable volume reduction of the venous malformation and a reduction in pain. Our observation warrants further research on the link between the RAS and venous malformations.http://www.sciencedirect.com/science/article/pii/S2468428722001769TherapeuticsVascular malformations |
| spellingShingle | Sigurd Berger, MD Therese Halvorsen Bjark, MD Karsten Midtvedt, MD, PhD Rune Andersen, MD Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension Journal of Vascular Surgery Cases and Innovative Techniques Therapeutics Vascular malformations |
| title | Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension |
| title_full | Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension |
| title_fullStr | Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension |
| title_full_unstemmed | Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension |
| title_short | Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension |
| title_sort | regression of a venous malformation during angiotensin converting enzyme inhibitor treatment for hypertension |
| topic | Therapeutics Vascular malformations |
| url | http://www.sciencedirect.com/science/article/pii/S2468428722001769 |
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