Rapid generation and characterization of recombinant HCoV-OC43-VR1558 infectious clones expressing reporter Renilla luciferase

Rapid generation and characterization of recombinant HCoV-OC43-VR1558 infectious clones expressing reporter Renilla luciferase

Viral infectious clones (ICs) serve as robust platforms for studying viral biology and screening antiviral agents using reverse genetics. However, the molecular profiles and complex limitations of human coronaviruses (HCoVs) pose a challenge to ICs development. In this study, we report a novel platf...

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Bibliographic Details
Main Authors: Fei Ye, Na Wang, Qiongge Guan, Mengwei Wang, Jiewei Sun, Desheng Zhai, Baoying Huang, Ying Zhao, Wenjie Tan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biosafety and Health
Subjects:
Infectious clones
Human coronaviruses (HCoV)-OC43
Transformation-associated recombination (TAR)
Reporter Renilla luciferase (Rluc)
Online Access:http://www.sciencedirect.com/science/article/pii/S259005362400137X

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http://www.sciencedirect.com/science/article/pii/S259005362400137X

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