Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

<h4>Background</h4>The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and path...

Full description

Bibliographic Details
Main Authors: Victoria A Lawson, Brooke Lumicisi, Jeremy Welton, Dorothy Machalek, Katrina Gouramanis, Helen M Klemm, James D Stewart, Colin L Masters, David E Hoke, Steven J Collins, Andrew F Hill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808809/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808809/pdf/?tool=EBI

Similar Items