Establishment and Characterization of a Stable Producer Cell Line Generation Platform for the Manufacturing of Clinical-Grade Lentiviral Vectors

Establishment and Characterization of a Stable Producer Cell Line Generation Platform for the Manufacturing of Clinical-Grade Lentiviral Vectors

<b>Background/Objectives:</b> To date, nearly 300 lentiviral-based gene therapy clinical trials have been conducted, with eight therapies receiving regulatory approval for commercialization. These advances, along with the increased number of advanced-phase clinical trials, have prompted...

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Bibliographic Details
Main Authors: Ane Arrasate, Igone Bravo, Carlos Lopez-Robles, Ane Arbelaiz-Sarasola, Maddi Ugalde, Martha Lucia Meijueiro, Miren Zuazo, Ana Valero, Soledad Banos-Mateos, Juan Carlos Ramirez, Carmen Albo, Andrés Lamsfus-Calle, Marie J. Fertin
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomedicines
Subjects:
lentiviral vectors
gene therapy
stable producer cell line
lentiviral packaging cell line
cell line development
Online Access:https://www.mdpi.com/2227-9059/12/10/2265

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https://www.mdpi.com/2227-9059/12/10/2265

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