MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca<sup>2+</sup> Uptake, Growth, and Infectivity of the Human Pathogen <named-content content-type="genus-species">Trypanosoma cruzi</named-content>

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca<sup>2+</sup> Uptake, Growth, and Infectivity of the Human Pathogen <named-content content-type="genus-species">Trypanosoma cruzi</named-content>

ABSTRACT The mitochondrial Ca2+ uptake in trypanosomatids, which belong to the eukaryotic supergroup Excavata, shares biochemical characteristics with that of animals, which, together with fungi, belong to the supergroup Opisthokonta. However, the composition of the mitochondrial calcium uniporter (...

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Bibliographic Details
Main Authors: Mayara S. Bertolini, Miguel A. Chiurillo, Noelia Lander, Anibal E. Vercesi, Roberto Docampo
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
MICU1
MICU2
Trypanosoma cruzi
calcium signaling
calcium uniporter
mitochondria
Online Access:https://journals.asm.org/doi/10.1128/mBio.00348-19

Internet

https://journals.asm.org/doi/10.1128/mBio.00348-19

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