Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes
Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13064-x |
| _version_ | 1830449852038774784 |
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| author | Yibo Zhang Wei Liu Zihang Li Vinay Kumar Ana L. Alvarez-Cabrera Emily C. Leibovitch Yanxiang Cui Ye Mei Guo-Qiang Bi Steve Jacobson Z. Hong Zhou |
| author_facet | Yibo Zhang Wei Liu Zihang Li Vinay Kumar Ana L. Alvarez-Cabrera Emily C. Leibovitch Yanxiang Cui Ye Mei Guo-Qiang Bi Steve Jacobson Z. Hong Zhou |
| author_sort | Yibo Zhang |
| collection | DOAJ |
| description | Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes. |
| first_indexed | 2024-12-21T08:05:22Z |
| format | Article |
| id | doaj.art-1062cc7672534646a1f32c8bd2fcbf60 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:05:22Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1062cc7672534646a1f32c8bd2fcbf602022-12-21T19:10:49ZengNature PortfolioNature Communications2041-17232019-11-0110111310.1038/s41467-019-13064-xAtomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexesYibo Zhang0Wei Liu1Zihang Li2Vinay Kumar3Ana L. Alvarez-Cabrera4Emily C. Leibovitch5Yanxiang Cui6Ye Mei7Guo-Qiang Bi8Steve Jacobson9Z. Hong Zhou10Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)California NanoSystems Institute, University of California, Los Angeles (UCLA)California NanoSystems Institute, University of California, Los Angeles (UCLA)California NanoSystems Institute, University of California, Los Angeles (UCLA)Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH)California NanoSystems Institute, University of California, Los Angeles (UCLA)State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University (ECNU)Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC)Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH)California NanoSystems Institute, University of California, Los Angeles (UCLA)Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes.https://doi.org/10.1038/s41467-019-13064-x |
| spellingShingle | Yibo Zhang Wei Liu Zihang Li Vinay Kumar Ana L. Alvarez-Cabrera Emily C. Leibovitch Yanxiang Cui Ye Mei Guo-Qiang Bi Steve Jacobson Z. Hong Zhou Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes Nature Communications |
| title | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes |
| title_full | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes |
| title_fullStr | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes |
| title_full_unstemmed | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes |
| title_short | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes |
| title_sort | atomic structure of the human herpesvirus 6b capsid and capsid associated tegument complexes |
| url | https://doi.org/10.1038/s41467-019-13064-x |
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