Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease

Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease

Individuals affected by Huntington's disease (HD) present with progressive degeneration that results in a wide range of symptoms, including cardiovascular (CV) dysfunction. The huntingtin gene (HTT) and its product are ubiquitously expressed, hence, the cardiomyopathy could also be driven by de...

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Bibliographic Details
Main Authors: Saemi Park, Shu Hon Christopher Luk, Raj S. Bains, Daniel S. Whittaker, Emily Chiem, Maria C. Jordan, Kenneth P. Roos, Cristina A. Ghiani, Christopher S. Colwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Huntington's disease
cardiac dysfunction
BACHD mouse model
rescue
hypertrophy
cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.810810/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.810810/full

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