Parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway

Parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway

Aluminum is a neurotoxic food contaminant. Aluminum trichloride (AlCl3) causes hippocampal mitochondrial damage, leading to hippocampal injury. Damaged mitochondria can release mitochondrial reactive oxygen species (mtROS) and activate nucleotide-binding oligomerization domain-like receptor-containi...

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Bibliographic Details
Main Authors: Siming Huo, Xuliang Zhang, Jinyu Xu, Jian Zhang, Jiayu Du, Bo Li, Miao Song, Bing Shao, Yanfei Li, Feibo Xu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aluminum
Parkin
Mitophagy
Mitochondrial reactive oxygen species
NLRP3-inflammasome
Neurodegenerative diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323009636

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http://www.sciencedirect.com/science/article/pii/S0147651323009636

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