The Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System

The Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System

The addition of N-acetyl glucosamine (GlcNAc) on the hydroxy group of serine/threonine residues is known as O-GlcNAcylation (OGN). The dynamic cycling of this monosaccharide on and off substrates occurs via O-linked β-N-acetylglucosamine transferase (OGT) and O-linked β-N-acetylglucosaminase (OGA) r...

Full description

Bibliographic Details
Main Authors: Michael P. Mannino, Gerald W. Hart
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
GlcNAc
immune system
post translational modification
protein-protein interactions
glycobiology
nutrient sensing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.828648/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.828648/full

Similar Items