Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions

Controlling Pericellular Oxygen Tension in Cell Culture Reveals Distinct Breast Cancer Responses to Low Oxygen Tensions

Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research, it is presumed that the incubator setpoint equals the O2 tension experienced by cells (i.e., pericellular O2). However, it is discovered that physioxic (5% O2) and hypoxic (1% O2) setpoints regularly induc...

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Bibliographic Details
Main Authors: Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov, Sidi A. Bencherif
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Advanced Science
Subjects:
anoxia
breast cancer
cancer metabolism
cell culture
hypoxia
hypoxia‐inducible factors
Online Access:https://doi.org/10.1002/advs.202402557

Internet

https://doi.org/10.1002/advs.202402557

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