Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Inflammation of brain endothelial cells is seen in neurodegenerative conditions and in aging. Here the authors examine the role of astrocytes in blood brain barrier function using an iPSC-derived cell co-culture model.

Bibliographic Details
Main Authors: Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Rebecca J. Embalabala, Kate Mlouk, Ketaki A. Katdare, Indigo V. L. Rose, Sarah M. Sturgeon, Emma H. Neal, Yan Ao, Shinong Wang, Michael V. Sofroniew, Jonathan M. Brunger, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34412-4

Internet

https://doi.org/10.1038/s41467-022-34412-4

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