A tumor mutational burden-derived immune computational framework selects sensitive immunotherapy/chemotherapy for lung adenocarcinoma populations with different prognoses

A tumor mutational burden-derived immune computational framework selects sensitive immunotherapy/chemotherapy for lung adenocarcinoma populations with different prognoses

BackgroundLung adenocarcinoma (LUAD) kills millions of people every year. Recently, FDA and researchers proved the significance of high tumor mutational burden (TMB) in treating solid tumors. But no scholar has constructed a TMB-derived computing framework to select sensitive immunotherapy/chemother...

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Bibliographic Details
Main Authors: Wenlong Zhang, Chuzhong Wei, Fengyu Huang, Wencheng Huang, Xiaoxin Xu, Xiao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Oncology
Subjects:
lung adenocarcinoma
tumor mutational burden
prediction of prognosis
immune landscape
immunotherapy
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1104137/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1104137/full

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