Including Volume Effects in Biological Treatment Plan Optimization for Carbon Ion Therapy: Generalized Equivalent Uniform Dose-Based Objective in TRiP98

Including Volume Effects in Biological Treatment Plan Optimization for Carbon Ion Therapy: Generalized Equivalent Uniform Dose-Based Objective in TRiP98

We describe a way to include biologically based objectives in plan optimization specific for carbon ion therapy, beyond the standard voxel-dose-based criteria already implemented in TRiP98, research planning software for ion beams. The aim is to account for volume effects—tissue architecture-depende...

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Bibliographic Details
Main Authors: Marco Battestini, Marco Schwarz, Michael Krämer, Emanuele Scifoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
volume effect in radiotherapy
generalized equivalent uniform dose (gEUD)
TRiP98
carbon ion therapy
treatment plan optimization
biological treatment planning
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.826414/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.826414/full

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