Nanobody-based CAR-T cells for cancer immunotherapy

Nanobody-based CAR-T cells for cancer immunotherapy

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy has been successful in treating various types of hematological cancers. CARs are receptors made of an extracellular doma...

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Bibliographic Details
Main Authors: Pouya Safarzadeh Kozani, Abdolhossein Naseri, Seyed Mohamad Javad Mirarefin, Faeze Salem, Mojtaba Nikbakht, Sahar Evazi Bakhshi, Pooria Safarzadeh Kozani
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Biomarker Research
Subjects:
Chimeric antigen receptor
Single-chain fragment variable
Nanobody
VHH
Solid tumors
Hematologic malignancy
Online Access:https://doi.org/10.1186/s40364-022-00371-7

Internet

https://doi.org/10.1186/s40364-022-00371-7

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