CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health

CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health

ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in t...

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Bibliographic Details
Main Authors: Matthew D. Smith, Simon Wilkinson
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Molecular & Cellular Oncology
Subjects:
selective autophagy
ccpg1
endoplasmic reticulum
pancreas
fip200
Online Access:http://dx.doi.org/10.1080/23723556.2018.1441631

Internet

http://dx.doi.org/10.1080/23723556.2018.1441631

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