CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health
ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1441631 |
| _version_ | 1797677126405586944 |
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| author | Matthew D. Smith Simon Wilkinson |
| author_facet | Matthew D. Smith Simon Wilkinson |
| author_sort | Matthew D. Smith |
| collection | DOAJ |
| description | ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here. |
| first_indexed | 2024-03-11T22:40:27Z |
| format | Article |
| id | doaj.art-10713737223e4268867b555ed8ff603c |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:27Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-10713737223e4268867b555ed8ff603c2023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-09-015510.1080/23723556.2018.14416311441631CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell healthMatthew D. Smith0Simon Wilkinson1MRC Institute of Genetics and Molecular Medicine, University of EdinburghMRC Institute of Genetics and Molecular Medicine, University of EdinburghER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here.http://dx.doi.org/10.1080/23723556.2018.1441631selective autophagyccpg1endoplasmic reticulumpancreasfip200 |
| spellingShingle | Matthew D. Smith Simon Wilkinson CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health Molecular & Cellular Oncology selective autophagy ccpg1 endoplasmic reticulum pancreas fip200 |
| title | CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health |
| title_full | CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health |
| title_fullStr | CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health |
| title_full_unstemmed | CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health |
| title_short | CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health |
| title_sort | ccpg1 an unconventional cargo receptor for er phagy maintains pancreatic acinar cell health |
| topic | selective autophagy ccpg1 endoplasmic reticulum pancreas fip200 |
| url | http://dx.doi.org/10.1080/23723556.2018.1441631 |
| work_keys_str_mv | AT matthewdsmith ccpg1anunconventionalcargoreceptorforerphagymaintainspancreaticacinarcellhealth AT simonwilkinson ccpg1anunconventionalcargoreceptorforerphagymaintainspancreaticacinarcellhealth |