Diagnosis of human leptospirosis: systematic review and meta-analysis of the diagnostic accuracy of the Leptospira microscopic agglutination test, PCR targeting Lfb1, and IgM ELISA to Leptospira fainei serovar Hurstbridge

Diagnosis of human leptospirosis: systematic review and meta-analysis of the diagnostic accuracy of the Leptospira microscopic agglutination test, PCR targeting Lfb1, and IgM ELISA to Leptospira fainei serovar Hurstbridge

Abstract Background Leptospirosis is an underdiagnosed infectious disease with non-specific clinical presentation that requires laboratory confirmation for diagnosis. The serologic reference standard remains the microscopic agglutination test (MAT) on paired serum samples. However, reported estimate...

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Bibliographic Details
Main Authors: Marta Valente, Justina Bramugy, Suzanne H. Keddie, Heidi Hopkins, Quique Bassat, Oliver Baerenbold, John Bradley, Jane Falconer, Ruth H. Keogh, Paul N. Newton, Mathieu Picardeau, John A. Crump
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Infectious Diseases
Subjects:
Leptospirosis
Meta-analysis
Agglutinations tests
Polymerase chain reaction
Enzyme-linked immunosorbent assay
Systematic review
Online Access:https://doi.org/10.1186/s12879-023-08935-0

Internet

https://doi.org/10.1186/s12879-023-08935-0

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