Sulindac Induces Apoptosis and Inhibits Tumor Growth In Vivo in Head and Neck Squamous Cell Carcinoma

Sulindac Induces Apoptosis and Inhibits Tumor Growth In Vivo in Head and Neck Squamous Cell Carcinoma

Sulindac has antineoplastic effects on various cancer cell lines; consequently, we assessed sulindac's effects on laryngeal squamous cell carcinoma (SCC) cells in vitro and in vivo. In vitro, SCC (HEP-2) cells treated with various cyclooxygenase inhibitors or transfected with constitutively act...

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Bibliographic Details
Main Authors: Mark A. Scheper, Nikolaos G. Nikitakis, Risa Chaisuparat, Silvia Montaner, John J. Sauk
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Sulindac
signal transducer and activator of transcription 3 (Stat3)
survivin
head and neck cancer
squamous cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800509

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