Stabilization of CCDC102B by Loss of RACK1 Through the CMA Pathway Promotes Breast Cancer Metastasis via Activation of the NF-κB Pathway

Stabilization of CCDC102B by Loss of RACK1 Through the CMA Pathway Promotes Breast Cancer Metastasis via Activation of the NF-κB Pathway

BackgroundBreast cancer is one of the leading causes of cancer-related death among women, and the pathological status of axillary lymph nodes is an important predictor of prognosis. However, the mechanism involved in this early stage of metastasis remains largely unknown.MethodsMicroarray analysis w...

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Bibliographic Details
Main Authors: Jing Si, Rong Guo, Bingqiu Xiu, Weiru Chi, Qi Zhang, Jianjing Hou, Yonghui Su, Jiajian Chen, Jingyan Xue, Zhi-Ming Shao, Jiong Wu, Yayun Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
breast cancer
CRISPR/Cas9
CCDC102B
RACK1
chaperone-mediated autophagy
NF-κB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.927358/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.927358/full

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