Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

The endocannabinoid anandamide (AEA) is an antinociceptive lipid that is inactivated through cellular uptake and subsequent catabolism by fatty acid amide hydrolase (FAAH). Fatty acid binding proteins (FABPs) are intracellular carriers that deliver AEA and related N-acylethanolamines (NAEs) to FAAH...

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Bibliographic Details
Main Authors: Martin Kaczocha, Mario J Rebecchi, Brian P Ralph, Yu-Han Gary Teng, William T Berger, William Galbavy, Matthew W Elmes, Sherrye T Glaser, Liqun Wang, Robert C Rizzo, Dale G Deutsch, Iwao Ojima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3976407?pdf=render

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http://europepmc.org/articles/PMC3976407?pdf=render

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