Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s due to the flexible and hydrophilic nature of...

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Bibliographic Details
Main Authors: Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
HSP70
cryptic pocket
fragment screen
virtual screen
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/27/3/817

Internet

https://www.mdpi.com/1420-3049/27/3/817

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