Clinical experience with multiplex ligation-dependent probe amplification for microdeletion syndromes in prenatal diagnosis: 7522 pregnant Korean women

Clinical experience with multiplex ligation-dependent probe amplification for microdeletion syndromes in prenatal diagnosis: 7522 pregnant Korean women

Abstract Background Conventional cytogenetic analysis using G-band karyotyping has been the method of choice for prenatal diagnosis, accurately detecting chromosomal abnormalities larger than 5 Mb. However, the method is inefficient for detecting the submicroscopic deletions and duplications that ar...

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Bibliographic Details
Main Authors: Dongsook Lee, Sohyun Na, Surim Park, Sanghee Go, Jinyoung Ma, Soonha Yang, Kichul Kim, Seunggwan Lee, Doyeong Hwang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Cytogenetics
Subjects:
Multiplex ligation-dependent probe amplification (MLPA)
MLPA P245
Prenatal diagnosis
Increased nuchal translucency
Microdeletion syndromes
Online Access:http://link.springer.com/article/10.1186/s13039-019-0422-8

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http://link.springer.com/article/10.1186/s13039-019-0422-8

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