Recombination Mediator Proteins: Misnomers That Are Key to Understanding the Genomic Instabilities in Cancer

Recombination mediator proteins have come into focus as promising targets for cancer therapy, with synthetic lethal approaches now clinically validated by the efficacy of PARP inhibitors in treating BRCA2 cancers and RECQ inhibitors in treating cancers with microsatellite instabilities. Thus, unders...

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Bibliographic Details
Main Authors: Justin Courcelle, Travis K. Worley, Charmain T. Courcelle
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/13/3/437