Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

Imprinting is a critical part of normal embryonic development in mammals, controlled by defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting control regions. Direct nanopore sequencing of DNA provides a means to detect allelic methylation and to overcome the d...

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Bibliographic Details
Main Authors: Vahid Akbari, Jean-Michel Garant, Kieran O'Neill, Pawan Pandoh, Richard Moore, Marco A Marra, Martin Hirst, Steven JM Jones
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
imprinting
nanopore sequencing
allele-specific methylation
DNA methylation
H3K36me3
H3K27me3
Online Access:https://elifesciences.org/articles/77898

Internet

https://elifesciences.org/articles/77898

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