Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation.

Nitrite is a nitric oxide (NO) metabolite in tissues and blood, which can be converted to NO under hypoxia to facilitate tissue perfusion. Although nitrite is known to cause vasodilation following its reduction to NO, the effect of nitrite on platelet activity remains unclear. In this study, the eff...

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Main Authors: Sirada Srihirun, Thanaporn Sriwantana, Supeenun Unchern, Dusadee Kittikool, Egarit Noulsri, Kovit Pattanapanyasat, Suthat Fucharoen, Barbora Piknova, Alan N Schechter, Nathawut Sibmooh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3262819?pdf=render