Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice

Antisense oligonucleotide (AON) therapy for Duchenne muscular dystrophy has drawn great attention in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few saponins for their potential to improve delivery...

Full description

Bibliographic Details
Main Authors: Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
saponin
antisense delivery
exon-skipping
PMO
muscular dystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300180

Internet

http://www.sciencedirect.com/science/article/pii/S2162253118300180

Similar Items