Impact of TSPO Receptor Polymorphism on [<sup>18</sup>F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

Impact of TSPO Receptor Polymorphism on [<sup>18</sup>F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [<sup>18</sup>F]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [<sup>...

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Bibliographic Details
Main Authors: Franziska J. Vettermann, Stefanie Harris, Julia Schmitt, Marcus Unterrainer, Simon Lindner, Boris-Stephan Rauchmann, Carla Palleis, Endy Weidinger, Leonie Beyer, Florian Eckenweber, Sebastian Schuster, Gloria Biechele, Christian Ferschmann, Vladimir M. Milenkovic, Christian H. Wetzel, Rainer Rupprecht, Daniel Janowitz, Katharina Buerger, Robert Perneczky, Günter U. Höglinger, Johannes Levin, Christian Haass, Joerg C. Tonn, Maximilian Niyazi, Peter Bartenstein, Nathalie L. Albert, Matthias Brendel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Life
Subjects:
microglia
neurodegeneration
Alzheimer’s disease
neuro-oncology
4R-tauopathy
TSPO-PET
Online Access:https://www.mdpi.com/2075-1729/11/6/484

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https://www.mdpi.com/2075-1729/11/6/484

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